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  Letztes Feedback
   27.11.12 21:43
       10.12.12 10:06
   
   13.05.13 17:57
   
There is certainly a lot
   15.05.13 03:04
    I wanted to thank you fo
   25.07.14 11:07
    Hmm it looks like your s
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    Analýza a porovn



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By 2007, Viagra's global share had plunged to about 50 percent due to several factors, including the entry of Cialis and Levitra, along with several counterfeits and clones, and reports of vision loss in people taking PDE5 inhibitors. In February 2007, it was announced that Boots the Chemist would try over the counter sales of Viagra in stores in Manchester, England. Men aged between 30 and 65 would be eligible to buy four tablets after a consultation with a pharmacist. Pfizer's worldwide patents on sildenafil citrate will expire in 2011–2013. The UK patent held by Pfizer on the use of PDE5 inhibitors (see below) as treatment of impotence was invalidated in 2000 because of obviousness; this decision was upheld on appeal in 2002. Mechanism of action The mechanism of action of Sildenafil citrate involves the release of nitric oxide (NO) in the corpus cavernosum of the penis. 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