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   25.11.17 15:35
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    Sie wollen die Beruhrung



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The 1998 FIFA World Cup, the 16th FIFA World Cup, was held in France from 10 June to 12 July 1998. France was chosen as host nation by FIFA on 2 July 1992. The tournament was won by France, which beat Brazil 3-0 in the final. France won its first title, becoming the seventh nation to win a World Cup, and the sixth nation (after Uruguay, Italy, England, West Germany and Argentina), to be both host and world champion. This was the first FIFA World Cup to host 32 national teams in the group round. The official match ball was the Adidas Tricolore. Qualification Main article: 1998 FIFA World Cup qualification Qualifying countries Four nations qualified for the World Cup for the first time: Croatia, Jamaica, Japan, and South Africa. [edit] Seeding Main article: 1998 FIFA World Cup seeding Germany, Italy, Argentina, Spain, Romania and the Netherlands were seeded along with defending champion Brazil and host France. For the first time in FIFA's history, the draw took place in a football stadium - Stade Vélodrome in Marseilles, on 4 December 1997. Norway was the last remaining European team in Pot 3, destined to be in Brazil or Argentina's group, which was the former.
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http://06-cup.3arhat.cz.cc/bellakh. Summary The format of the competition was different from 1994, as the finals were expanded from 24 to 32 teams. The 32 teams were divided into eight groups of four. The eight group winners and the eight group runners-up would qualify for the knockout stage. Starting in this tournament, all teams had to travel in group stage, and stadiums held matches for multiple groups. The golden goal rule was also introduced to decide knockout matches which went into extra time. Another change in the rules came into effect at this World Cup, stating that as regulation time was about to expire in any period of play the fourth official would use a handheld electronic display to show how many minutes of stoppage time were to be played. This practice has continued since then, after being well received by media and spectators alike. The tournament opened with 1994 FIFA World Cup champions Brazil's 2-1 victory over Scotland. Norway pulled the shock of Group A, topping the holders 2-1 after two late goals. Still, both teams advanced to the next round. Italy easily won Group B, with Chile's three draws enough for them to get through. The Italy-Chile clash which ended 2-2 saw Italy's Roberto Baggio cast aside the spectre of his miss in the penalty shootout in the final 4 years earlier: this time around his highly controversial spot-kick earned Italy a draw. France 98 mascot. France swept Group C, with the lone blemish being the red card expulsion and two-game suspension of Zinedine Zidane in a 4-0 win over Saudi Arabia. Denmark also moved on from the group. Nigeria was the surprise winner of Group D, dubbed the group of death, as Spain once again failed to live up to high pre-cup expectations. Nigeria beat them 3-2 in a thrilling game and moved on to the next round together with Paraguay. Netherlands and Mexico moved on from Group E, a group that saw four games end in draws. Mexico came from behind in two of those four games that ended in a draw after being down two goals in both games. Germany and Yugoslavia made easy work of Group F. A late goal for Romania saw them beat England 2-1 and take the top spot in Group G; the English finished second. Argentina swept Group H, joined by Croatia in the second round. In the second round, Italy beat Norway 1-0 and Brazil made easy work of Chile, 4-1. Laurent Blanc of France scored the first Golden Goal in World Cup history as the hosts beat Paraguay 1-0. Denmark surprised Nigeria, crushing them 4-1. Germany beat Mexico and Netherlands topped Yugoslavia by identical 2-1 scores. Croatia upset Romania 1-0. Argentina beat England on penalties after drawing 2-2 in a game that saw a stunning goal from 18-year-old Michael Owen, and two fairly debatable penalty awards (one for each side) which were both scored. The game was marred by England's David Beckham being sent off after kicking Diego Simeone: despite being a man down, England fashioned the better chances and were unfortunate that an extra-time goal by Sol Campbell was disallowed after Alan Shearer was, also debatably, adjudged to have fouled the Argentine keeper. France beat Italy in the quarter-finals on penalties after a scoreless draw. Brazil topped Denmark 3-2 in an exciting game. Croatia pulled perhaps the biggest shocker of the tournament, crushing Germany 3-0. The Netherlands-Argentina match was marred by violence; the Netherlands was reduced to 10 men early on after a tackle by Artur Numan injured Diego Simeone and Simeone had to be carried off the field for treatment. Late in the match, Argentina star Ariel Ortega received a red card for head-butting Dutch goalkeeper Edwin van der Sar after van der Sar confronted Ortega on the latter's play-acting attempt to draw a penalty[1]. Shortly after Ortega's sending off, Dennis Bergkamp of the Netherlands scored a memorable goal, finishing from a 60-yard pass to eliminate Argentina 2-1. In the semi-finals, striker Patrick Kluivert equalized late for the Netherlands to make it 1-1, but the Brazilians won on penalties. They were joined by France, as veteran defender Lilian Thuram scored two goals with stunning runs from the right hand side of the pitch to overcome Golden Boot winner Davor Šuker's opener for Croatia. The Croats beat the Dutch for third place. For the first time ever, the final featured the host nation and the defending champions. Zinedine Zidane scored two headers from corners in the 27th minute and in first half stoppage time, and Emmanuel Petit added a late goal in second half stoppage time to give France a 3-0 win over Brazil. An estimated one million people took to the Paris streets to celebrate through the night. France became the seventh country to have won the world cup, joining Uruguay, Italy, Germany, Brazil, England and Argentina. The official song for the event was The Cup of Life by Ricky Martin, and the official anthem was La Cour des Grands by Youssou N'Dour and Axelle Red. [edit] Mascot The official mascot of this World Cup was Footix, a cockerel with the words "FRANCE 98" on the chest. Its body is mostly blue, like the host's national team shirt and its name is a portmanteau of "football" and the ending "-ix" from the popular Astérix comic strip. word cup 2010 worlcup 2010 worl cup 2010 worldcup 06 worldcup 2010 worldcup 2010 accommodation worldcup 2010 ball worldcup 2010 fixtures worldcup 2010 game worldcup 2010 group worldcup 2010 groups worldcup 2010 qualification worldcup 2010 schedule worldcup 2010 south africa worldcup 2010 stadiums worldcup 2010 teams worldcup 2010 tickets worldcup 2010 wiki worldcup 2014 worldcup 2018 worldcup 2022 worldcup final worldcup finals worldcup fixture worldcup fixtures worldcup match worldcup matches worldcup qualifying 2010 world cups 2010 worldcup schedule worldcup scores worldcup southafrica worldcup stadiums worldcup standings worldcup teams world soccer 2010 usa soccer 2006 usa soccer 2010 usa soccer live usa soccer match usa soccer matches usa soccer schedule usa soccer tv usa soccer worldcup worldcup 06 worldcup 1998 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27.6.10 21:37


Weather

Weather is the state of the atmosphere as measured on a scale of hot or cold, wet or dry, calm or storm, clear or cloudy.[1] Most weather phenomena occur in the troposphere,[2][3] just below the stratosphere. Weather refers, generally, to day-to-day temperature and precipitation activity, whereas climate is the term for the average atmospheric conditions over longer periods of time.[4] When used without qualification, "weather" is understood to be the weather of Earth. Weather occurs due to density (temperature and moisture) differences between one place and another. These differences can occur due to the sun angle at any particular spot, which varies by latitude from the tropics. The strong temperature contrast between polar and tropical air gives rise to the jet stream. Weather systems in the mid-latitudes, such as extratropical cyclones, are caused by instabilities of the jet stream flow. Because the Earth's axis is tilted relative to its orbital plane, sunlight is incident at different angles at different times of the year. On Earth's surface, temperatures usually range ±40 °C (100 °F to −40 °F) annually. Over thousands of years, changes in Earth's orbit affect the amount and distribution of solar energy received by the Earth and influence long-term climate Surface temperature differences in turn cause pressure differences. Higher altitudes are cooler than lower altitudes due to differences in compressional heating. Weather forecasting is the application of science and technology to predict the state of the atmosphere for a future time and a given location. The atmosphere is a chaotic system, so small changes to one part of the system can grow to have large effects on the system as a whole. Human attempts to control the weather have occurred throughout human history, and there is evidence that human activity such as agriculture and industry has inadvertently modified weather patterns. Studying how the weather works on other planets has been helpful in understanding how weather works on Earth. A famous landmark in the Solar System, Jupiter's Great Red Spot, is an anticyclonic storm known to have existed for at least 300 years. However, weather is not limited to planetary bodies. A star's corona is constantly being lost to space, creating what is essentially a very thin atmosphere throughout the Solar System. The movement of mass ejected from the Sun is known as the solar wind.
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On Earth, common weather phenomena include wind, cloud, rain, snow, fog and dust storms. Less common events include natural disasters such as tornadoes, hurricanes, typhoons and ice storms. Almost all familiar weather phenomena occur in the troposphere (the lower part of the atmosphere).[3] Weather does occur in the stratosphere and can affect weather lower down in the troposphere, but the exact mechanisms are poorly understood.[5] Weather occurs primarily due to density (temperature and moisture) differences between one place to another. These differences can occur due to the sun angle at any particular spot, which varies by latitude from the tropics. In other words, the farther from the tropics you lie, the lower the sun angle is, which causes those locations to be cooler due to the indirect sunlight.[6] The strong temperature contrast between polar and tropical air gives rise to the jet stream.[7] Weather systems in the mid-latitudes, such as extratropical cyclones, are caused by instabilities of the jet stream flow (see baroclinity).[8] Weather systems in the tropics, such as monsoons or organized thunderstorm systems, are caused by different processes. Because the Earth's axis is tilted relative to its orbital plane, sunlight is incident at different angles at different times of the year. In June the Northern Hemisphere is tilted towards the sun, so at any given Northern Hemisphere latitude sunlight falls more directly on that spot than in December (see Effect of sun angle on climate).[9] This effect causes seasons. Over thousands to hundreds of thousands of years, changes in Earth's orbital parameters affect the amount and distribution of solar energy received by the Earth and influence long-term climate. (see Milankovitch cycles).[10] Uneven solar heating (the formation of zones of temperature and moisture gradients, or frontogenesis) can also be due to the weather itself in the form of cloudiness and precipitation.[11] Higher altitudes are cooler than lower altitudes, which is explained by the lapse rate.[12][13] On local scales, temperature differences can occur because different surfaces (such as oceans, forests, ice sheets, or man-made objects) have differing physical characteristics such as reflectivity, roughness, or moisture content. Surface temperature differences in turn cause pressure differences. A hot surface heats the air above it and the air expands, lowering the air pressure and its density.[14] The resulting horizontal pressure gradient accelerates the air from high to low pressure, creating wind, and Earth's rotation then causes curvature of the flow via the Coriolis effect.[15] The simple systems thus formed can then display emergent behaviour to produce more complex systems and thus other weather phenomena. Large scale examples include the Hadley cell while a smaller scale example would be coastal breezes. The atmosphere is a chaotic system, so small changes to one part of the system can grow to have large effects on the system as a whole.[16] This makes it difficult to accurately predict weather more than a few days in advance, though weather forecasters are continually working to extend this limit through the scientific study of weather, meteorology. It is theoretically impossible to make useful day-to-day predictions more than about two weeks ahead, imposing an upper limit to potential for improved prediction skill.[17] Chaos theory says that the slightest variation in the motion of the ground can grow with time. This idea is sometimes called the butterfly effect, from the idea that the motions caused by the flapping wings of a butterfly eventually could produce marked changes in the state of the atmosphere. 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http://viagra.arhat.cz.cc/seerorusmabo. Mechanism of action The mechanism of action of Sildenafil citrate involves the release of nitric oxide (NO) in the corpus cavernosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries, resulting in increased inflow of blood and an erection. Robert F. Furchgott won the Nobel Prize in Physiology or Medicine in 1998 for his discovery and analysis of endothelium-derived relaxing factor, a key part of the NO mechanism of action. Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra).
22.6.10 20:03


Cancer

Cancer /ˈkænsə(r)/ ( listen) (medical term: malignant neoplasm) is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via lymph or blood). These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, and do not invade or metastasize. Most cancers form a tumor but some, like leukemia, do not. 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http://secondary.ahrat.co.cc/xanteer. Definitive diagnosis requires the histologic examination of a biopsy specimen, although the initial indication of malignancy can be symptomatic or radiographic imaging abnormalities. Most cancers can be treated and some cured, depending on the specific type, location, and stage. Once diagnosed, cancer is usually treated with a combination of surgery, chemotherapy and radiotherapy. As research develops, treatments are becoming more specific for different varieties of cancer. There has been significant progress in the development of targeted therapy drugs that act specifically on detectable molecular abnormalities in certain tumors, and which minimize damage to normal cells. The prognosis of cancer patients is most influenced by the type of cancer, as well as the stage, or extent of the disease. In addition, histologic grading and the presence of specific molecular markers can also be useful in establishing prognosis, as well as in determining individual treatments. Classification Further information: List of cancer types Cancers are classified by the type of cell that resembles the tumor and, therefore, the tissue presumed to be the origin of the tumor. These are the histology and the location, respectively. Examples of general categories include: * Carcinoma: Malignant tumors derived from epithelial cells. This group represents the most common cancers, including the common forms of breast, prostate, lung and colon cancer. * Sarcoma: Malignant tumors derived from connective tissue, or mesenchymal cells. * Lymphoma and leukemia: Malignancies derived from hematopoietic (blood-forming) cells * Germ cell tumor: Tumors derived from totipotent cells. In adults most often found in the testicle and ovary; in fetuses, babies, and young children most often found on the body midline, particularly at the tip of the tailbone; in horses most often found at the poll (base of the skull). * Blastic tumor or blastoma: A tumor (usually malignant) which resembles an immature or embryonic tissue. Many of these tumors are most common in children. Malignant tumors (cancers) are usually named using -carcinoma, -sarcoma or -blastoma as a suffix, with the Latin or Greek word for the organ of origin as the root. For instance, a cancer of the liver is called hepatocarcinoma; a cancer of the fat cells is called liposarcoma. For common cancers, the English organ name is used. For instance, the most common type of breast cancer is called ductal carcinoma of the breast or mammary ductal carcinoma. Here, the adjective ductal refers to the appearance of the cancer under the microscope, resembling normal breast ducts. Benign tumors (which are not cancers) are named using -oma as a suffix with the organ name as the root. For instance, a benign tumor of the smooth muscle of the uterus is called leiomyoma (the common name of this frequent tumor is fibroid). Unfortunately, some cancers also use the -oma suffix, examples being melanoma and seminoma. Signs and symptoms Symptoms of cancer metastasis depend on the location of the tumor. Roughly, cancer symptoms can be divided into three groups: * Local symptoms: unusual lumps or swelling (tumor), hemorrhage (bleeding), pain and/or ulceration. Compression of surrounding tissues may cause symptoms such as jaundice (yellowing the eyes and skin). * Symptoms of metastasis (spreading): enlarged lymph nodes, cough and hemoptysis, hepatomegaly (enlarged liver), bone pain, fracture of affected bones and neurological symptoms. Although advanced cancer may cause pain, it is often not the first symptom. * Systemic symptoms: weight loss, poor appetite, fatigue and cachexia (wasting), excessive sweating (night sweats), anemia and specific paraneoplastic phenomena, i.e. specific conditions that are due to an active cancer, such as thrombosis or hormonal changes. Every symptom in the above list can be caused by a variety of conditions (a list of which is referred to as the differential diagnosis). Cancer may be a common or uncommon cause of each item. Causes Cancer is a diverse class of diseases which differ widely in their causes and biology. Any organism, even plants, can acquire cancer. Nearly all known cancers arise gradually, as errors build up in the cancer cell and its progeny (see mechanisms section for common types of errors). Anything which replicates (our cells) will probabilistically suffer from errors (mutations). Unless error correction and prevention is properly carried out, the errors will survive, and might be passed along to daughter cells. Normally, the body safeguards against cancer via numerous methods, such as: apoptosis, helper molecules (some DNA polymerases), possibly senescence, etc. However these error-correction methods often fail in small ways, especially in environments that make errors more likely to arise and propagate. For example, such environments can include the presence of disruptive substances called carcinogens, or periodic injury (physical, heat, etc.), or environments that cells did not evolve to withstand, such as hypoxia[5] (see subsections). Cancer is thus a progressive disease, and these progressive errors slowly accumulate until a cell begins to act contrary to its function in the animal. The errors which cause cancer are often self-amplifying, eventually compounding at an exponential rate. For example: * A mutation in the error-correcting machinery of a cell might cause that cell and its children to accumulate errors more rapidly * A mutation in signaling (endocrine) machinery of the cell can send error-causing signals to nearby cells * A mutation might cause cells to become neoplastic, causing them to migrate and disrupt more healthy cells * A mutation may cause the cell to become immortal (see telomeres), causing them to disrupt healthy cells forever Thus cancer often explodes in something akin to a chain reaction caused by a few errors, which compound into more severe errors. Errors which produce more errors are effectively the root cause of cancer, and also the reason that cancer is so hard to treat: even if there were 10,000,000,000 cancerous cells and one killed all but 10 of those cells, those cells (and other error-prone precancerous cells) could still self-replicate or send error-causing signals to other cells, starting the process over again. This rebellion-like scenario is an undesirable survival of the fittest, where the driving forces of evolution itself work against the body's design and enforcement of order. In fact, once cancer has begun to develop, this same force continues to drive the progression of cancer towards more invasive stages, and is called clonal evolution.[6] Research about cancer causes often falls into the following categories: * Agents (e.g. viruses) and events (e.g. mutations) which cause or facilitate genetic changes in cells destined to become cancer. * The precise nature of the genetic damage, and the genes which are affected by it. * The consequences of those genetic changes on the biology of the cell, both in generating the defining properties of a cancer cell, and in facilitating additional genetic events which
21.6.10 21:36


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Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra). Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent, research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease). The first clinical trials were conducted in Morriston Hospital in Swansea. Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections. Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the US Food and Drug Administration on March 27, 1998, becoming the first oral treatment approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year. It soon became a great success: annual sales of Viagra in the period 1999–2001 exceeded $1 billion.[citation needed] The British press portrayed Peter Dunn and Albert Wood as the inventors of the drug, a claim that Pfizer disputes. Their names are on the manufacturing patent application drug, but Pfizer claims this is only for convenience.[citation needed] Even though sildenafil is available only by prescription from a doctor, it was advertised directly to consumers on U.S. TV (famously being endorsed by former United States Senator Bob Dole and soccer star Pelé. Numerous sites on the Internet offer Viagra for sale after an "online consultation", often a simple web questionnaire.[citation needed] The "Viagra" name has become so well known that many fake aphrodisiacs now call themselves "herbal Viagra" or are presented as blue tablets imitating the shape and colour of Pfizer's product. Viagra is also informally known as "Vitamin V", "the Blue Pill", as well as various other nicknames. In 2000, Viagra sales accounted for 92 percent of the global market for prescribed erectile dysfunction pills. By 2007, Viagra's global share had plunged to about 50 percent due to several factors, including the entry of Cialis and Levitra, along with several counterfeits and clones, and reports of vision loss in people taking PDE5 inhibitors. In February 2007, it was announced that Boots the Chemist would try over the counter sales of Viagra in stores in Manchester, England. Men aged between 30 and 65 would be eligible to buy four tablets after a consultation with a pharmacist. Pfizer's worldwide patents on sildenafil citrate will expire in 2011–2013. The UK patent held by Pfizer on the use of PDE5 inhibitors (see below) as treatment of impotence was invalidated in 2000 because of obviousness; this decision was upheld on appeal in 2002. Mechanism of action The mechanism of action of Sildenafil citrate involves the release of nitric oxide (NO) in the corpus cavernosum of the penis. 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Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra). Sildenafil is metabolised by liver enzymes and excreted by both the liver and kidneys. If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third. Uses Sexual dysfunction The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now standard treatment for erectile dysfunction in all settings, including diabetes. People on antidepressants may experience sexual dysfunction, either as a result of their illness or as a result of their treatment. A 2003 study showed that sildenafil improved sexual function in men in this situation. Following up to earlier reports from 1999, the same researchers found that sildenafil was able to improve sexual function in female patients on antidepressants as well. Pulmonary hypertension As well as erectile dysfunction, sildenafil citrate is also effective in the rare disease pulmonary arterial hypertension (PAH). It relaxes the arterial wall, leading to decreased pulmonary arterial resistance and pressure. This, in turn, reduces the workload of the right ventricle of the heart and improves symptoms of right-sided heart failure. Because PDE-5 is primarily distributed within the arterial wall smooth muscle of the lungs and penis, sildenafil acts selectively in both these areas without inducing vasodilation in other areas of the body. Pfizer submitted an additional registration for sildenafil to the FDA, and sildenafil was approved for this indication in June 2005. The preparation is named Revatio, to avoid confusion with Viagra, and the 20 milligram tablets are white and round. Sildenafil joins bosentan and prostacyclin-based therapies for this condition.
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